Setting up Photoshop to produce pixel perfect web designs requires taking control of your application settings and tool options.
Controlling Your Settings:
Set up Photoshop for pixel perfect web layouts: Configure Photoshop for pixel perfect design
Making pixel perfect adjustments: Pixel Perfect Rotation & Nudging
Creating Grids:
Cameron McEfee GuideGuide a Photoshop plug-in to create custom guides.
960 Grid System a very good online tool for creating grids.
Online grid creation system Lets you save your grid as a Photoshop pattern.
Grid Designer Another online grid creation tool.
GridCalc Grid calculator and generator
Tutorials:
How to create a sleek grid based website design
Photoshop web layout tutorials
More Photoshop web layout tutorials
Working with vectors
Not related to Web Design, but WOW!
The end of blurred images
And who needs to focus in the first place?
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